Here's a short vort I saw recently in the Kedushas Levi:
Based on the order of the letters in the Aleph-Beis:
Samech, Ayin, Peh, Tzadi:
Samech is the only letter in the whole aleph-beis that is closed on all sides [apparantly he's not counting the end letters].
So, the message is:
Samech--close you're Ayin [eyes] from seeing bad things, and close your PEH [mouth] from saying bad words...
and then you'll be a TZADDIk!